Analysis performed on 2024-07-10 11:38:54
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 64500 | 753 | 63747 | 11946 |
| Archaea | 3183 | 107 | 3076 | 1382 |
| Vertebrata | 789 | 254 | 535 | 427 |
| Mammals | 238 | 33 | 205 | 124 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 739 | 107 | 648 |
| Domains | |
|---|---|
| Current Study | 1, 116 | 725, 740 |
| Guo et al (2010) | 2, 61 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 608 | 131 | 739 | 4.641221 |
| Number of Variants | 580 | 175 | 755 | 3.314286 |
| Number of Pathogenic Variants | 92 | 15 | 107 | 6.133333 |
| Number of Benign/Unknown Variants | 488 | 160 | 648 | 3.050000 |
| Fisher exact test | 0.013600 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 679 | 60 | 739 | 11.316667 |
| Number of Variants | 658 | 97 | 755 | 6.783505 |
| Number of Pathogenic Variants | 102 | 5 | 107 | 20.400000 |
| Number of Benign/Unknown Variants | 556 | 92 | 648 | 6.043478 |
| Fisher exact test | 0.004603 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 608 | 131 | 0.95 (0.00) | 0.76 (0.02) | 9.891e-01 | 8.087e-01 | 66247.00 | 2.23e-33 |
| Guo et al (2010) | 679 | 60 | 0.94 (0.00) | 0.60 (0.02) | 9.870e-01 | 5.724e-01 | 39163.00 | 4.96e-33 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.